Eslicarbazepine acetate Pharmaceutical Intermediates CAS NO 236395-14-5 99%

Eslicarbazepine acetate  Pharmaceutical Intermediates  CAS NO 236395-14-5  99%​

Quick Detail:

Description:

> Formula:C17H16N2O3

> Weight: 296.32

> Appearance:White or off-white crystalline powder

> MP:183-185°C

> Storage:2-8℃

> Danger Description:R36/37/38

> Safety  Description:S26-36

> Danger Symbol:Xi

> Shelf life:two years

Specifications

Synonyms:

(S)-(-)-10-ACETOXY-10,11-DIHYDRO-5H-DIBENZO/B,F/AZEPINE-5-CARBOXAMIDE-;(10S)-10-(Acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxaMide;Sep 0002093;(S)-5-CarbaMoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate;(10S)-10-(Acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; BIA 2-093

Related categories:APIs;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals

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Determination of melting point

   Instrument:

   Micro melting point apparatus WRS-2A, Melting point tubes

  Determination of step:

Open switch, stable 20min.

First set the starting temperature than the melting point of the low 10 ℃, heating rate 2 ℃ / min.

The sample was grind as fine as possible and load in a clean, dry melting point pipe ,until the sample was compressed into about 1cm high .When the actual temperature reaches the set temperature and stabilized . Inserted into the capillary with the sample, the simultaneous determination of three.

The determination of Loss on drying

  Weigh a sample of approximately 2g (weighing accuracy 0.0001g),Record the weight of m,The sample was placed in a Petri dish constant weight (weight recorded as m0), the tile, the thickness of not more than 5mm, into the oven (As next dish cover removed) drying at 105-110 ℃ 3 hours.When removing, make sure the dish cover,be placed in a desiccator to cool, then weighed and the weight (including surface dish) m1.

Loss on drying in accordance with the following formula:

Where:

         m-- sample, g

       m0-- dish, g

          m1-- After drying the quality of the sample and the dish, g

The determination of residue on ignition

   First the Griddle was burning 30 minutes at 600 ± 50 ℃, cooled and then weighed on a silica gel drier.Taking 1g sample was placed in a crucible and weighed, with 2ml sulfuric acid (5.5ml98% sulfuric acid diluted to 100ml) wetting the sample which was slowly heated until the sample completely low zoom.Cooling,using 2ml sulfuric acid (5.5ml98% sulfuric acid diluted to 100ml) to wet the sample, which was slowly heated until no white smoke, and then placed at 600 ±50℃ calcined to obtain the residue, to ensure that the entire process does not  produce white smoke.Cooling Griddle silica gel dryer and then weighed to calculate the mass of the residue.