Lovastatin(CAS No. 75330-75-5)

Name:Lovastatin
CAS Registry number:75330-75-5
Synonyms:
Antibiotic MB 530B;Lestatin;
Lovastatine [French];6-alpha-Methylcompactin
Appearance:White solid
Density:1.12 g/cm3
Color/Form:
White crystals,A white, nonhygroscopic crystalline powder
Usage:
An antihypercholesterolemic agent. A fungal metabolite, which is a potent inhibitor of HMG-CoA reductase

Biological Activity:
Potent, competitive inhibitor of HMG-CoA reductase (K i = 0.6 nM) therefore decreases cholesterol biosynthesis, in vitro and in vivo . Decreases CDK2, 4, 6 and cyclin E levels and induces G1 arrest and apoptosis in tumor cell lines in vitro .
Pharmacological Action:
- Substances used to lower plasma cholesterol levels.
- Compounds that inhibit HMG-CoA reductases. They have been shown to directly lower cholesterol synthesis.
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