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CAS No. | 103060-53-3 | Grade Standard | Medicine Grade | MF | C72H101N17O26 |
---|---|---|---|---|---|
Other Names | Daptomycin | Place of Origin | China | Purity | 98% |
Type | Anesthetic Agents, Antibiotic and Antimicrobial Agents |
Name | Daptomycin |
Molecular Formula | C72H101N17O26 |
Molecular Weight | 1620.67 |
CAS Registry Number | 103060-53-3 |
Off-White to Light Yellow Solid
Residue on ignition≤1.0%
Anhydro-daptomycin≤2.5%
β-Isomer≤ 2.0%
Lactone hydrolysis product≤1.5%
RS-2≤ 0.50%
Any other unknown impurity≤0.15%
Total impurities≤ 7.0%
Heavy metals≤30ppm
Water≤10.0% (K.F.)
Bacterial endotoxins<0.3EU/mg
Acetone≤5000ppm
Isopropanol≤5000ppm
Ethanol≤5000ppm
Butyl alcohol≤5000PPm
Assay (Dried bases)≥95.0%
Daptomycin is a kind of cyclic lipopeptide antibiotics with novel structure. It is extracted from the Streptomyces fermentation broth. It not only having a novel chemical structure but also has mode of action which is different from any antibiotic approved before: it inhibits cell by disrupting the transport of amino acids through cell membrane, thereby blocking the cell wall peptidoglycan biosynthesis and changing the nature of the cell membrane. It can destroy the bacterial cell membrane function in many aspects, and quickly kill gram-positive bacteria. In addition to the role of taking effect on most clinically relevant gram-positive bacteria, more importantly, Daptomycin has a potent efficacy in treating isolated strains which have shown signs of resistance to methicillin, vancomycin and linezolid. This property is of great clinical significance to patients suffering from severe infection.
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